Subacute Sclerosing Panencephalitis: Experimental Infection in Primates

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Abstract
Measles virus isolated from the brain of a 12-year-old boy with subacute sclerosing panencephalitis caused a chronic, progressive encephalitis in experimentally infected rhesus monkeys. The infection was eventually fatal in spite of pre-existing measles immunity and a vigorous secondary antibody response in serum and cerebrospinal fluid of the infected animals. The findings provide a basis for studies into the pathogenesis and possible treatment of the human disease.