Allopurinol and Cytotoxic Drugs

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Abstract
In 160 patients with neoplastic diseases (other than leukemia) that were treated with cytotoxic drugs, bone marrow depression (BMD) was more common in 65 patients who also received allopurinol than in 95 who did not (P<.005). In 58 patients who received cyclophosphamide, the frequencies of BMD in allopurinol recipients and nonrecipients were 57.7% and 18.8%, respectively. A similar but less pronounced trend occurring with other cytotoxic drugs involved too few patients with any one drug to allow firm conclusions. Interaction between allopurinol and cytotoxic drugs is a possible explanation of these findings.