Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid)
- 1 January 1975
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 2 (12) , 2305-2314
- https://doi.org/10.1093/nar/2.12.2305
Abstract
Poly (2-methylthioinosinic acid) [poly(ms2I)] was found to markedly inhibit the RNA directed DNA polymerase (reverse transcriptase) activity of murine (Moloney, Rauscher) leukemia virus and murine (Moloney) sarcoma virus, while under the same conditions the unsubstituted parent compound poly(I) showed little, if any, inhibitory effect. Copolymers of inosinic acid (I) and 2-methylthioinosinic acid2(ms2I) showed an intermediary effect, depending on the I:ms2I ratio. Poly(ms2I) also inhibited the transformation of normal cells by murine (Moloney) sarcoma virus, as assessed by an infectious center assay.Keywords
This publication has 27 references indexed in Scilit:
- Antiviral activity of partially thiolated polynucleotides.1975
- Antiviral activity of polynucleotides: copolymers of inosinic acid and N2-dimethylguanylic or 2-methylthioinosinic acidNucleic Acids Research, 1975
- DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabileNature, 1974
- Inhibition of RNA directed DNA polymerase of murine leukemia virus by 2′-O-alkylated polyadenylic acidsBiochemical and Biophysical Research Communications, 1974
- Poly(2'-O-methylcytidylate).oligodeoxyguanylate as a template for the ribonucleic acid directed deoxyribonucleic acid polymerase in ribonucleic acid tumor virus particles and a specific probe for the ribonucleic acid directed enzyme in transformed murine cellsBiochemistry, 1974
- A more sensitive assay system for the detection of RNA-dependent DNA polymerase in oncogenic RNA virusesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
- Inhibition of Murine Leukemia Virus Replication by Poly(vinyluracil) and Poly(vinyladenine)Proceedings of the National Academy of Sciences, 1973
- DNA Polymerases from RNA Tumor Viruses and Human Cells: Inhibition by Polyuridylic AcidScience, 1972
- Distinguishing Reverse Transcriptase of an RNA Tumor Virus from Other Known DNA PolymerasesProceedings of the National Academy of Sciences, 1971
- Primer Requirement and Template Specificity of the DNA Polymerase of RNA Tumor VirusesProceedings of the National Academy of Sciences, 1971