Generalized neonatal herpes virus infection (cytomegalovirus or herpes virus type 1) comparative examination of loci attacked by two viruses3,4

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Abstract
Two autopsy cases, a 5‐minute‐old male infant with congenital cytomegalovirus (CMV) infection and a 10‐day‐old female infant with herpes simplex virus type 1 (HSV‐1) infection, were presented. CMV antibody titer detectable by immunofluorescence (IF) technique was significantly high in the sera of both infant and mother in the CMV case. In another HSV‐1 case, we have succeeded in HSV‐1 isolation from autopsy liver and subsequent serological identification of the isolated virus, including a detection of high HSV‐1 antibody titer in the mother's serum by IF. On light and electron microscopes, these two cases respectively showed typical findings as the severest form of each viral infection. As one of the marked differences between the two cases, the thymus in the HSV‐1 case showed remarkable involution with a complete disappearance of thymic cortical lymphocytes. However, the CMV case exhibited an existence of intact thymus without viral injuries. Similar distinguishable differences between the two cases were observed also in the bone marrow. It additionally seems to be unique that cytomegalic inclusion bodies were disclosed fairly well in the submaxillary glands and rarely in the renal tubules even in the case with HSV‐1. ACTA PATHOL. JPN. 34: 847∼858, 1984.