Effect of Some Steroids and of Corticotropin (ACTH) on Cellular Activity

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Abstract
Cortisone acetate (2.5 mg. in 10 cc. of sea water) tends to suppress the incidence of normal cleavage in fertilized Arbacia punctulata ova and to inactivate spermatozoa. The vehicle does not alter the cleavage pattern. Compound F (5 mg. in 10 cc. of sea water) suspended in propylene glycol, desoxycorticosterone acetate, and the glucoside suppress normal cleavage of the fertilized ova. 2-6 mg. of ACTH directly affects the cleavage pattern of Arbacia ova. Testosterone propionate (2.5 mg.) and growth hormone had no effect on the incidence of normal cleavage in Arbacia ova. The suppressing action of ACTH is not a protein effect and it is not due to any differential solubility of the hormone.