Loperamide in severe protracted diarrhoea.

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Abstract
Six infants with severe, life-threatening, protracted diarrhea were treated with loperamide. Steady-state perfusion studies of the jejunum showed that in 2 of them the small intestine was in a net secretory state with respect to water, and, in the others, this was inferred from the fact that the diarrhea persisted despite nothing by mouth. Loperamide resulted in a prompt and impressive improvement in the condition of each infant. This drug apparently has an important role in the management of protracted diarrheal states in some infants who are unresponsive to current treatments, and its effect may be related to its antisecretory action.