A Pilot Study of Heel Ultrasound to Screen for Low Bone Mass in Children With Leukemia

Abstract
The optimal method to assess pediatric bone mass remains controversial. Dual x-ray absorptiometry (DXA) is commonly used but quantitative ultrasound is less expensive, free of ionizing radiation, and predicts fractures as well as DXA does, in adults. Broadband ultrasound attenuation (BUA) was determined using a portable calcaneal ultrasonometer and, compared with DXA derived areal bone mineral density (BMD) values in 42 young patients (ages 4.5 to 20.3 y) with leukemia. Reduced BMD was defined as a DXA z score of