Studies in Olfactory Acuity: III. Relative Detectability of n-Aliphatic Acetates by the Rat

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Abstract
The ability of black and albino rats to detect the first seven n-aliphatic acetates in the vapour phase has been investigated by use of an odour choice box. Both the median threshold and the slope of the probit regression line (which describes the relation between concentration and response) tend to decrease logarithmically in value as the series is ascended. The position of methyl acetate in these relations appears anomalous. When expressed as thermodynamic activities median thresholds for acetates of intermediate chain length are about equally stimulating, whilst short chain alcohols excite at decreasing activities with increasing chain length. The close similarity of these findings to those reported in the previous study on n-aliphatic alcohols supports the view that such relations may be of more general occurrence in olfaction in the rat. The stimulus-response curve for each acetate studied shows one or more reversals in slope. It is suggested that certain of these are due to the presence of two or more olfactory receptor types one or more of which attain maximum response at lower concentrations of a given acetate than do the remainder. The asymptotes of the curves are reached in about 2–3 log units of concentration.

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