Mammary Neoplasia in Partial-Body-Irradiated Rats Treated with AET

Publisher Website
Google Scholar
Abstract
When AET [aminoethyl isothiouronium] was combined with 400 R of anterior body irradiation to 42-day-old female rats, the AET-treated animals lived longer than similarly irradiated, nonprotected littermates. Mammary neoplasia was much more prevalent in the irradiated portion of the animals than in the shielded, posterior portion. AET did not change the incidence of rats with mammary neoplasma, nor the total number of mammary neoplasms of various types when calculated on a rat-day at risk basis in the irradiated area, nor the incidence of mammary neoplasia in the shielded area, nor the incidence of other neoplasms in either area. The failure of AET to modify this scopal, neoplastic response was contrasted to previous reports that chemical radioprotective agents did modify the neoplastic response to total-body irradiation. It was suggested that, where these agents do act to modify the neoplastic response to irradiation, the modification may be at a site far removed from the interaction of the radiation and the tissue that is to develop neoplasia.