Amelioration of hydroxyurea‐induced suppression of phagocytosis in human granulocytes by free radical scavengers

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Abstract
The exposure of human circulatory white cells in vitro to 0.1-1-10 mol/l hydroxyurea (HU) for 20 h induced a progressive dose-dependent suppression of the phagocytic activity of granulocytes. The suppressing effect of 20 h exposure to 1 mol/l HU was used to examine the protection afforded by free radical scavengers against HU-induced cytotoxicity. In the suitable concentration of the protecting agent, a substantial protective effect of sodium benzoate, acetylosalicylic acid, .alpha.-tocopherol, ascorbic acid, catalase, peroxidase or superoxide dismutase can be achieved.