Fast Alkene Functionalization In Vivo by Photoclick Chemistry: HOMO Lifting of Nitrile Imine Dipoles
- 1 July 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 48 (29) , 5330-5333
- https://doi.org/10.1002/anie.200901220
Abstract
Extremely fast fluorescence labeling (Escherichia coli cells was observed with tetrazole 1. The electron‐donating methoxy substituent raises the energy of the highest occupied molecular orbital of the nitrile–imine intermediate derived from 1. This strategy greatly accelerates the functionalization of alkenes by 1,3‐dipolar cycloaddition in living systems. magnified imageKeywords
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