The Tuberculostatic Action of Streptothricin and Streptomycin with Special Reference to the Action of Streptomycin on the Chorioallantoic Membrane of the Chick Embryo

Publisher Website
Google Scholar
Abstract
The report presents the results of expts. (a) on the tuberculostatic action of streptothricin and streptomycin in vitro, (b) the toxicity of the 2 drugs to the developing chick embryo, and (c) the tuberculostatic action of streptomycin as detd. by the extent of tubercle development after the inoculation of the drug-bacillary suspension on the chorio-allantoic membrane. The expts. in vitro indicate that streptomycin is 20 times more active than streptothricin and that 0.3 mg. per 100 ml. is sufficient to give complete inhibition in vitro. Streptothricin was found to be 4 times more toxic to the developing chick than streptomycin. The expts. on the development of tubercles after inoculation of the drug-bacillary suspension indicate that 1500 units of streptomycin per mg. of tubercle bacilli markedly inhibit tubercle development in the chorio-allantoic membrane of the chick embryo.