Novel Human Leukocyte Interferon Subtype and Structural Comparison of Alpha Interferon Genes
- 1 January 1984
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 4 (4) , 609-617
- https://doi.org/10.1089/jir.1984.4.609
Abstract
In the cDNA library of virus-induced human leukocytes a novel subtype of IFN-α gene has been identified and sequenced, named IFN-α-N. A comparison of nucleotide sequences within the genes coding for different subtypes of human leukocyte interferon (IFN-α) has revealed the natural hybrid structure of individual α-IFNs-H,B,F, and N. Certain regions of the genes for IFN-α-H,B,F,N show a homology with one of the two structurally distinct groups of leukocyte interferons—either IFN-α-A,D or IFN-α-C,C1 utilized as reference standards.Keywords
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