Effect of Thiouracil and Estrogen on Lactogenic Hormone and Weight of Pituitaries of Rats

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Abstract
The admn. of 0.1% thiouracil in the feed for 24 days to young [female] rats significantly reduced the lactogenic hormone content of the pituitary below that in control rats. Estrogen alone or in combination with thiouracil induced equal increases in pituitary lactogen when given for 21 days. However, when rats received thiouracil alone for a 2 wk. preliminary period, the subsequent admn. of estrogen plus thiouracil failed to evoke an increase in pituitary lactogen content. In fact, the lactogenic hormone was as low as in the group which received thiouracil alone. Thiouracil alone or in combination with estrogen was found to be more effective in increasing pituitary wt. than estrogen alone. Thiouracil was somewhat more effective in increasing thyroid weight than when given together with estrogen. The relation of these findings to the cytologic changes reportedly induced in the hypophysis by goiterogens and estrogens are discussed.

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