The Effect of Prostaglandin F2α on Ovarian Blood Flow and Progesterone Concentrations in Cyclic Guinea Pigs1

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Abstract
Prostaglandin [PG] F2.alpha. may provoke luteolysis in guinea pigs indirectly by causing changes in ovarian blood flow. To test this hypothesis, 15 .mu.m and 25 .mu.m radiolabeled microspheres were injected into guinea pigs before and after treatment with saline or a dose of PGF2.alpha. which resulted in a significant decrease in plasma progesterone [P] concentrations. The percentage of cardiac output to the ovaries and the percentage of arteriole-venule shunting within the ovaries, estimated by the number of microspheres in this tissue, were unchanged 6 h after treatment, yet plasma P concentrations were significantly reduced in the PGF2.alpha. treated animals. These results, although confirming the luteolytic action of PGF2.alpha. in guinea pigs, suggest that its mode of action does not require the intervention of hemodynamic adjustments.
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