SELECTIVE GROWTH OF RABBIT CORNEAL EPITHELIAL-CELLS IN CULTURE AND BASEMENT-MEMBRANE COLLAGEN-SYNTHESIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 19  (10) , 1222-1230
Abstract
Selective isolation of rabbit corneal epithelial cells was achieved with a medium containing D-valine. Long-term cultures of the epithelial cells synthesize basement membrane-type procollagen doublet chains of 160,000 and 180,000 daltons and a higher MW species of 280,000 daltons. Some of these components are disulfide-linked. These peptides gave rise to a single pepsin-resistant collagen chain of about 115,000 daltons.