SICKLE CELL ANEMIA IN WHITE PATIENTS WITH ULCERS OF THE ANKLES

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Abstract
Sickle cell anemia, since it was described by Herrick in 1910,1 has been known almost exclusively as a disease of the Negro race. However, after the report of Cooley and Lee in 1929, numerous instances of the disease have been reported in patients mostly of Greek, Sicilian and Italian extraction, thought to be without Negro ancestors.2 The white patients mentioned in these reported cases have presented evidence of sickle cell anemia, including sickling, greenish yellow scleras, hepatomegaly, splenomegaly, pains in the joints, arms or legs and occasionally abdominal crises. All available case histories of the disease in the white race have failed to mention or have noted the absence of ulcerations or scars of the ankles or legs. It is our purpose to report on 2 patients from one family, 1 male and 1 female, with ulcers of the ankles and limitation of motion about the ankle joints.

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