INDUCTION AND CHEMOTHERAPEUTIC RESPONSE OF 2 TRANSPLANTABLE DUCTAL ADENOCARCINOMAS OF THE PANCREAS IN C57BL-6 MICE

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (2) , 717-726
Abstract
Two pancreatic ductal adenocarcinomas, both on C57BL/6 origin (Panc 02 and 03), were established. Panc 02 was treated with 37 anticancer drugs representing all of the chemical and functional classes of clinically useful anticancer agents including alkylating agents, antimetabolites, agents that bind to or cause scission of DNA, and others that inhibit mitosis or inhibit protein synthesis. When drug treatment was started within 3-4 days after tumor implant, Panc 02 showed only limited response to treatment with N''-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea, monohydrochloride and N-(2-chloroethyl)-N''-(2,6-dioxo-3-piperdinyl)-N-nitrosourea) and N-phosphonacetyl-L-aspartate. Drug response of Panc 03 was determined only with Adriamycin, 5-fluorouracil, cyclophosphamide, cis-(SP-4-2)-diamminedichloroplatinum, or N,N''-bis(2-chloroethyl)-N-nitrosourea. When drug treatment was started 3 days after tumor implant, high cure rates were obtained with Adriamycin treatment, and limited therapeutic responses were seen to treatment with cis-diamminedichloroplatinum or cyclophosphamide. A comparison of the biological characteristics and drug responsiveness of Panc 02 and Panc 03 with those of a number of other transplantable tumors of mice is reported.