The determination of mean residence time using statistical moments: Is it correct?
- 1 February 1985
- journal article
- research article
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 13 (1) , 93-100
- https://doi.org/10.1007/bf01073658
Abstract
The estimation of mean residence time using statistical moment theory is shown to lead to the true mean residence time only in the case of a concentration-time curve which is a single exponential. In other cases, including the commonly encountered double exponential, there is a systematic error present which can lead to the result being incorrect by as much as a factor of 2. For the case of instantaneous input, an alternative estimation procedure is suggested which gives an estimate much closer to the true mean residence time.Keywords
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