AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN ACUTE MYELOID-LEUKEMIA IN RELAPSE OR IN COMPLETE REMISSION

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (11) , 1983-1985
Abstract
Ten cases of acute myeloid leukemia treated by intensive therapy followed by autologous bone marrow transplantation are reported. Seven patients were in 1st relapse; 3 were in complete remission. The conditioning regimen consisted of chemotherapy alone (6-thioguanine, cytarabine, lomustine and cyclophosphamide [TACC; 8 patients]) or cyclophosphamide and total-body irradiation (2 patients). All the patients in 1st relapse achieved complete remission (CR). The median remission duration was 9.9 mo. (range, 5-14); the median survival was 14.4 mo. (range, 9-23.8). Of the 3 patients autografted during CR, 1 relapsed at 5 mo. and 2 others remain in CR and are well at 18+ and 18.3+ mo. High-dose chemotherapy followed by autologous bone marrow transplantation seems to be a valuable treatment for acute myeloid leukemia, if it is used immediately after the CR to consolidate the remission.