INDUCTION OF MACROPHAGE GROWTH BY LIPOPROTEIN

  • 1 January 1985
    • journal article
    • research article
    • Vol. 55  (1) , 29-35
Abstract
Cell-free tumorous ascitic fluid stimulated growth of variously induced mouse peritoneal macrophages and resident macrophages in vitro. This induction of macrophage growth by the tumorous ascitic fluid was confirmed by autoradiography. The macrophage growth-stimulating activity was stable with heating at 100.degree. C, in contrast to that of macrophage growth factor (colony stimulating factor) previously reported. This heat-stable macrophage growth-stimulating activity was recovered in the lipoprotein fraction of tumorous ascitic fluid. The lipoprotein from heat-treated normal mouse serum also induced growth of macrophages. Lipoprotein can induce macrophage proliferation, at least in vitro.

This publication has 2 references indexed in Scilit: