Changes in Hemodynamics and Bradykinin Concentration in Coronary Sinus Blood in Experimental Coronary Artery Occlusion

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Abstract
The parameters studied before and after acute occlusion of the anterior descending branch of the left coronary artery in 17 dogs were bradykinin (BK) in the coronary sinus blood, heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular [maximum change in pressure with time] (LV max dp/dt) and an index of myocardial contractility (LV max dp/dt/IP). BK levels increased, reaching a maximum of 30 .+-. 13 ng/ml 2 min after coronary ligation, accompanied by a significant elevation of LVEDP, and lowering of the myocardial contractility index. HR and LV max dp/dt showed no significant changes. There was a positive correlation between the level of BK and LVEDP, and a negative correlation between the level of BK and both LVSP and the myocardial contractility index. Pretreatment with aprotinin (Trasylol), an inhibitor of kinin-forming enzyme, prevented the increase in BK and LVEDP after coronary artery ligation and caused an elevation of the myocardial contractility index. BK formed within ischemic myocardium probably exerts a negative inotropic action on the heart.