Circulatory response to bradykinin before and after autonomic nervous system blockade

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Abstract
Atropine, 0.25 mg/kg, to reproduce parasym-pathetic block, phenoxybenzamine, 2.0-5.0 mg/kg, to block alpha ad-renergic receptors, and MJ-199[Sotalol], 1.0-3.0 mg/kg, to block beta receptors were used as specific blocking agents. The degree of block was assessed by administering specific stimulating agents, acetylcholine, isoproterenol, and Synephrin, and assumed to be complete when the response was reduced to 15% of the control response. Bradykinin produced peripheral vasodilatation and significant reductions in aortic pressure, systemic vascular resistance, and hindlimb vascular resistance; while cardiac output and stroke volume increased. Little direct myocardial effect was noted. The circulatory response to bradykinin was qualitatively similar after autonomic blockade. The circulatory action of bradykinin is primarily peripheral vasodilatation and this response is not mediated by way of the autonomic nervous system.