Active Polypeptides Derived From Plasma Proteins

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Abstract
The author treats of the main factors which take part in the formation of vasodilator and smooth muscle stimulating polypeptides. The general pattern consists of an inactive precursor plus an activator, giving rise to plasma kinin forming enzymes; these in turn react with plasma globulin to produce a plasma kinin, the active substance. He discusses each of these factors, and various inhibitory or inactivating ones which can intervene in, as well as terminate, the chain of reactions. Then he discusses the possible significance of the active peptides in different types of hyperemia: human skin blood flow, reactive hyperemia, reactions to local injury, antidromic vasodilatation, circulatory shock and related phenomena, migraine headaches, and inflammatory disease of the central nervous system.

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