Nonspecific suppressive effect of bovine herpesvirus type 1 on bovine leukocyte functions

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Abstract
The effect of bovine herpesvirus type 1 on the specific and nonspecific immune response of calves was examined. Animals with or without prior aerosol exposure to Pasteurella haemolytica sertoype A1 were aerosol challenged with 108 plaque-forming units of virus. Blood and serum samples were taken before and after virus challenge for determining cell-mediated, humoral and neutrophil responses. A significant depression of the blastogenic responses to phytohemagglutinin, P. haemolytica and Pasteurella multocida and of neutrophil chemotactic response was observed 4-7 days after challenge. The antibacterial activity of neutrophils was not significantly affected by virus exposure. Anti-bovine herpesvirus type 1 antibody responses were detected 11 days postchallenge. A significant elevation of the anti-P. haemolytica antibody response (day 0 vs. day +11) was detected in animals previously exposed to P. haemolytica.