A CLINICAL COMPARISON OF MODIFIED INSULINS 12

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Abstract
Each of 5 insulin prepns. (the "2:1 mixture," especially modified insulin types WPC - 40 and NPH - 50, standard protamine Zn insulin, and globin insulin with Zn) were tested in each of 19 women with diabetes mellitus under routine but controlled hospital conditions. The patients were divided into a relatively stable and a relatively unstable group on the basis of the variability in their levels of blood and urinary sugar. The insulins were compared on the basis of their ability to influence the extent and pattern of this variability. It was found that the insulins show no differential ability to control the extent of variability in either blood or urinary sugar levels. The pattern of variability differs considerably among the insulins in the unstable patients but not in the stable patients. The first 3 insulins listed do not display consistently high or low sugar levels at any given time of the day. Globin insulin with Zn gives a pattern of high sugar levels early in the day and low levels late in the day. Standard protamine Zn insulin produces a pattern opposite to that of globin insulin with Zn.
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