Transzervikale Chorionbiopsie - Bisherige Erfahrungen und Ergebnisse aus mehr als 200 Fällen*

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Abstract
This is a report on more than 228 chorionic biopsies performed at the Department of Gynaecology of the University of Heidelberg [Heidelberg, West Germany] After having completed the pilot study (about 100 cases before planned termination of pregnancy) with a success rate of 87% in obtaining useful chorionic villi, we initiated chorionic biopsy for diagnostic purposes. A cytogenetic result was obtained in 95% of all cases after the villi had been sampled, using the method of transcervical aspiration. In 1% of the cases the obtained tissue could not be used; in another 1% a chromosomal mosaiclike pattern was seen, whereas in 3% of the cases no cytogentic result was obtained despite the fact that partly the available tissue quantities were quite sufficient. No fast sex diagnosis was made in any of the examined cases. In 98% of all instances of sampling of chorionic villi, a sufficient amount of useful chorionic villi tissue was obtained. Vaginal bleeding after chorionic biopsy occurred only in about one-third of the cases within 1-7 days after sampling. In another third of the patients questioned accordingly, no vaginal bleeding was reported following chorionic villi sampling. The remaining patients stated that there had been only short-term haemorrhages after biopsy. 122 of 226 patients have since delivered, 39 are at present in 16th to 28th week of gestation, 41 beyond the 28th week and the remaining 13 were before the 16th week and the remaining 13 were before the 16th week at the time they were questioned. Abortion or fetal death after chorionic biopsy was seen in four cases only (1,8%). No malformations were seen so far in the delivered infants. Termination of pregnancy because of eugenic indications was necessary in seven cases (3%) as a result of the examination, but there were no complications. The main indication for chorionic villi sampling was seen in patients whose age at delivery was relatively advanced (older than 38 years) (75% of all patients). About 80% would be willing to undergo another chorionic villi sampling in case they were pregnant once more. Because of the low complication rate, transcervical chorionic villi sampling under sonographic monitoring can be regarded as an alternative examination method for the prupose of genetic amniocentesis and is quite recommended, taking into account the above mentioned precautions under controlled study conditions.