Failure to detect naturally occurring serum inhibitors of hepatitis B virus deoxyribonucleic acid polymerase

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Abstract
Sera of patients with past or ongoing hepatitis B virus [HBV] infection were tested for the presence of inhibitors of HBV-specific DNA polymerase activity. None of the sera tested, which included those from anti-hepatitis B surface[HBs]- and anti-HB core antigen[HBcAg]-positive hemophiliacs, anti-HBcAg-positive HBsAg carriers, patients with HBsAg-positive chronic active hepatitis, HBsAg-positive hemodialysis patients, tumor patients with minimal hepatitis, patients with acute type B, type A and type non-A, non-B hepatitis and individuals with autoimmune phenomena contained inhibitors of DNA polymerase activity. The DNA polymerase test may not be affected when used to quantitate DNA-containing Dane particles. There is no evidence that inhibitors of DNA polymerase activity play some pathogenic role in the course of HBV infection.