A DOUBLE‐BLIND TRIAL OF SINGLE‐DOSE CHEMOPROPHYLAXIS WITH CO‐TRIMOXAZOLE DURING VAGINAL HYSTERECTOMY AND REPAIR

Abstract
Summary: Twenty‐five patients received 10 ml co‐trimoxazole (800 mg sulphamethoxazole and 160 mg trimethoprim) and 25 a placebo by intravenous infusion during one hour from the commencement of surgery for vaginal hysterectomy with anterior colporrhaphy and posterior colpo‐perineorrhaphy. Single‐dose chemoprophylaxis with co‐trimoxazole was shown to be effective in reducing the incidence of post‐operative febrile morbidity and urinary tract infection, especially that caused by Proteus species.