Acetoxycycloheximide-Induced Transient Amnesia: Protective Effects of Adrenergic Stimulants
- 1 February 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (2) , 340-342
- https://doi.org/10.1073/pnas.69.2.340
Abstract
It has previously been shown that rats trained 5 hr after intracerebral injection of acetoxycycloheximide show a transient amnesia at 24 hr after training. We have tested the possibility that adrenergic stimulants might provide protection from the amnesia. Metaraminol, given either before or after training or before testing, prevents the drug-induced amnesia. D-Amphetamine, injected soon after training, also prevents the amnesia. A model is presented to explain the drug-induced amnesia in terms of both the assumed effect of acetoxycycloheximide on the adrenergic system and prevention of the amnesia by metaraminol and D-amphetamine.Keywords
This publication has 12 references indexed in Scilit:
- Effects of hydrocortisone and cycloheximide on blood-brain barrier function in the rat.1971
- Amnesia Produced by Electroconvulsive Shock or Cycloheximide: Conditions for RecoveryScience, 1970
- Some Evidence for the Involvement of Adrenergic Sites in the Memory TraceProceedings of the National Academy of Sciences, 1970
- Arousal and the conversion of "short-term" to "long-term" memory.Proceedings of the National Academy of Sciences, 1968
- Effect of Acetoxycycloheximide on Learning and Memory of a Light–Dark DiscriminationNature, 1968
- Reversal of the reserpine-induced suppression of the conditioned avoidance response by L-dopa: correlation of behavioral and biochemical differences in two strains of mice.1968
- Delayed and sustained effect of acetoxycycloheximide on memory in mice.Proceedings of the National Academy of Sciences, 1967
- Memory in Mice Analyzed with AntibioticsScience, 1967
- Stages of memory in mice treated with acetoxycycloheximide before or immediately after learning.Proceedings of the National Academy of Sciences, 1966
- Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.Proceedings of the National Academy of Sciences, 1966