Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.
- 1 February 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (2) , 369-374
- https://doi.org/10.1073/pnas.55.2.369
Abstract
Intracerebral injections of acetoxycycloheximide caused profound inhibition of cerebral protein synthesis but, unlike injections of puromycin, were without effect on memory of simple maze learning in mice. Intracerebral injection of a mixture of the 2 antibiotics, which also caused profound inhibition of cerebral protein synthesis, protected memory against the destructive effects of puromycin when injected alone. An effort is made to explain these observations in terms of the preservation of quantitative changes in messenger RNA which may accompany a learning experience.Keywords
This publication has 17 references indexed in Scilit:
- Memory and cerebral protein synthesis in mice as affected by graded amounts of puromycinExperimental Neurology, 1965
- Reversible inhibition of interferon synthesis by puromycin: evidence for an interferon-specific messenger RNA.Proceedings of the National Academy of Sciences, 1965
- Memory fixation in the goldfish.Proceedings of the National Academy of Sciences, 1965
- LOSS OF MEMORY AS RELATED TO INHIBITION OF CEREBRAL PROTEIN SYNTHESIS*Journal of Neurochemistry, 1965
- A differentiation in RNA response in neurons early and late during learning.Proceedings of the National Academy of Sciences, 1965
- PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINSProceedings of the National Academy of Sciences, 1964
- Inhibition of Protein Synthesis in vitro by CycloheximideNature, 1963
- Inhibition of the synthesis of protein in intact animals by acetoxycycloheximide and a metabolic derangement concomitant with this blockadeBiochemical Pharmacology, 1963
- Memory in Mice as Affected by Intracerebral PuromycinScience, 1963
- A modified ninhydrin colorimetric analysis for amino acidsArchives of Biochemistry and Biophysics, 1957