A Synthetic Lectin for O‐Linked β‐N‐Acetylglucosamine
- 17 February 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 48 (10) , 1775-1779
- https://doi.org/10.1002/anie.200804905
Abstract
Changing employment: Receptor 1 binds β‐N‐acetylglucosaminyl (β‐GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, 1 is more selective than WGA. It favors especially the glycoside unit in glycopeptide 2, a model of the serine‐O‐GlcNAc posttranslational protein modification.Keywords
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