Molecular Analysis of the High-Hemoglobin-F Phenotype in Saudi Arabian Sickle Cell Anemia
- 29 January 1987
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 316 (5) , 244-250
- https://doi.org/10.1056/nejm198701293160504
Abstract
Patients from the eastern province of Saudi Arabia who have sickle cell anemia have high circulating levels of fetal hemoglobin (hemoglobin F, 17 percent), and they therefore have a mild form of the disease. To examine the molecular basis of the elevated production of hemoglobin F, we searched for mutations in the promoter regions of the two hemoglobin F gamma-globin genes (Gγ and Aγ).This publication has 44 references indexed in Scilit:
- Five adults with mild sickle cell anemia share a βs chromosome with the same haplotypeAmerican Journal of Hematology, 1985
- The Ratio of the Gγ and Aγ Chains: Variations due to Anomalies at the Molecular LevelAnnals of the New York Academy of Sciences, 1985
- Hematologically and Genetically Distinct Forms of Sickle Cell Anemia in AfricaNew England Journal of Medicine, 1985
- G to A substitution in the distal CCAAT box of the Aγ-globin gene in Greek hereditary persistence of fetal haemoglobinNature, 1985
- Hematological Observations on Arabian SS Patients with a Homozygosity or Heterozygosity for a βSChromosome with Haplotype #31Hemoglobin, 1985
- Linkage Analysis of Nondeletion Hereditary Persistence of Fetal HemoglobinScience, 1982
- Hb F Synthesis in Sickle Cell Anaemia: a Comparison of Saudi Arab Cases with those of African OriginBritish Journal of Haematology, 1980
- Erythroid Progenitors Circulating in the Blood of Adult Individuals Produce Fetal Hemoglobin in CultureScience, 1978
- Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituScience, 1977
- BENIGN SICKLE-CELL ANÆMIAThe Lancet, 1972