Five adults with mild sickle cell anemia share a βs chromosome with the same haplotype
- 31 October 1985
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 20 (3) , 297-300
- https://doi.org/10.1002/ajh.2830200313
Abstract
Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (βs chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the βs # 31 chromosome promotes the synthesis of γ chains.Keywords
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