Pleuropulmonary Reaction to Nitrofurantoin

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Abstract
NITROFURANTOIN is frequently used for short and long term treatment of urinary tract infections. As with many drugs, various types of allergic or toxic reactions have occurred, the most serious of which is anaphylactic shock.1 An unusual reaction to nitrofurantoin consisting of pulmonary infiltration and pleural effusion was reported by Israel and Diamond in May, 1962.2 Three other reports have appeared in the foreign literature.3-5 Because of its rarity of occurrence, but alarming picture that it may present, this case is presented. Report of a Case A 31-year-old white female was referred to the Woodland Memorial Hospital on April 23, 1963, complaining of chills, fever, and dyspnea. About three weeks before admission, she developed symptoms of a urinary tract infection and her physician started treatment with sulfisoxazole on April 9, 1963. This was changed to nitrofurantoin, 100 mg four times daily, on April 17, because of persisting

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