Supporting Role of Vasodilators in Inducing Regressions of the Ehrlich Solid Tumor.

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Abstract
When mice bearing established, solid Ehrlich carcinomas were treated with NaNO2, penta-erythritol tetranitrate (PETN), or isosorbide dinitrate, there was an increase in the localization of Evans blue dye in the tumors. Epinephrine caused a decrease in the dye recovered from the tumors. When mice bearing solid Ehrlich tumors were treated with pentaerythritol tetranitrate, heterologous antitumor serum (adsorbed with mouse blood cells), and normal guinea pig serum, 60% of the tumors regressed if treatment was continued for 5 weeks or longer. Dosage of PETN required and period of time during which treatment had to be continued to avoid re-growth of the tumors.