Growth inhibition of leukaemic cells carrying the t(3;21) by the AML1/EVI‐1 ‐specific antisense oligonucleotide
- 1 July 1995
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 90 (3) , 711-714
- https://doi.org/10.1111/j.1365-2141.1995.tb05606.x
Abstract
Summary. The t(3;21)(q26;q22) translocation is thought to play an important role in the acute phase transformation of CML. The formation of the AML1/EVI-1 fusion gene by the translocation leads to expression of the AML1/EVI-1 fusion protein. Here we demonstrate that the AML1/EVI-1-specific antisense oligonucleotide markedly decreases the [H]thymidine incorporation and growth of leukaemic cells carrying the t(3;21) and the t(9;22), but not those of K562 cells. These results indicate that the AML1/EVI-1 fusion protein could contribute to proliferation of the t(3;21)-carrying leukaemic cells after entering the blastic crisis phase of CML.Keywords
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