Abstract
The publication in this issue of the paper by Madrazo et al.1 is an important event in the history of the treatment of Parkinson's disease. With this report, neural transplantation is with us as a possible mode of therapy. We need to understand it and develop adequate criteria to evaluate its use. This problem is most readily addressed by reviewing the development of our knowledge of Parkinson's disease, its treatment, and the experimental background for a clinical application of neural transplantation.The syndrome described by James Parkinson in 18172 is among the most common and readily recognized of neurologic entities . . .