Dose-Response Relationships between Glucocorticoids and Growth Inhibition in Rat Glioma Monolayer Cultures

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Abstract
Cell proliferation is inhibited in rat glioma (strain C6) monolayer cultures treated with cortisol (> 1 .mu.M) or dexamethasone (> 0.001 .mu.M). Transient growth inhibitory responses occur at 3 .mu.M cortisol and 0.01-0.03 .mu.M dexamethasone. At higher glucocorticoid concentrations, nontransient inhibitory responses persist for 5 days. Dose-response curves show that dexamethasone is 250-300 times more potent than cortisol in suppressing C6 growth.