T cell receptor vβ repertoire of double‐negative α/β t cells in patients with systemic sclerosis
Open Access
- 1 August 1992
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 35 (8) , 944-948
- https://doi.org/10.1002/art.1780350815
Abstract
Objective. To analyze the T cell receptor Vβ gene on double‐negative (DN) α/β T cells, which are increased in number, on peripheral blood lymphocytes (PBL) from patients with systemic sclerosis (SSc).Methods. The DN α/β T cells were sorted by flow cytometry from PBL obtained from 3 patients with SSc. The Vβ repertoire was analyzed by polymerase chain reaction.Results. Only 1 or 2 Vβ genes (Vβ5/7, 5, or 17) were predominantly expressed on DN α/β T cells from these 3 patients.Conclusion. The Vβ repertoire on DN α/β T cells in PBL from patients with SSc is rather restricted.Keywords
This publication has 15 references indexed in Scilit:
- T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients.Journal of Clinical Investigation, 1992
- Elevated production of interferon‐γ and interleukin 4 by mature T cells from autoimmune Ipr mice correlates with Pgp‐1 (CD44) expressionEuropean Journal of Immunology, 1991
- Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice.The Journal of Experimental Medicine, 1990
- Differentiation potential of subsets of CD4−8− thymocytesNature, 1987
- Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genesCell, 1987
- Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigenNature, 1987
- The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene familyCell, 1985
- The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytesCell, 1985
- Sequence and expression of transcripts of the human T-cell receptor β- chain genesNature, 1984
- Preliminary criteria for the classification of systemic sclerosis (scleroderma)Arthritis & Rheumatism, 1980