Role of metabolism and pharmacokinetic studies in the discovery of new drugs—present and future perspectives
- 1 January 1992
- journal article
- review article
- Published by Taylor & Francis in Xenobiotica
- Vol. 22 (7) , 743-755
- https://doi.org/10.3109/00498259209053137
Abstract
1. The impact which pharmacokinetics and drug metabolism studies have made to drug discovery programmes is reviewed with examples from the anti-infective, cardiovascular, anti-inflammatory and CNS therapeutic areas. 2. Contributions that advances in analytical technology have made to the early application of pharmacokinetics and drug metabolism are discussed. 3. Some future perspectives are given on the advances being made in basic science and technology and how this will provide the basis for further growth in the contribution to the drug discovery process.Keywords
This publication has 24 references indexed in Scilit:
- EFFECTS OF UK 69 578: A NOVEL ATRIOPEPTIDASE INHIBITORPublished by Elsevier ,1989
- A phased approach to drug developmentJournal of Pharmacokinetics and Biopharmaceutics, 1989
- Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residueJournal of Medicinal Chemistry, 1989
- Oral absorption of cephalosporin antibiotics. 1. Synthesis, biological properties and oral bioavailability of 7-arylacetamido-3-chloro cephalosporins in animalsJournal of Medicinal Chemistry, 1988
- Metabolic synthesis of arylacetic acid antiinflammatory drugs from arylhexenoic acids. 2. IndomethacinJournal of Medicinal Chemistry, 1987
- Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamideJournal of Medicinal Chemistry, 1987
- Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenololXenobiotica, 1986
- Peptides and Related Drugs: A Review of Their Absorption, Metabolism, and ExcretionDrug Metabolism Reviews, 1986
- Pharmacokinetics and Toxicity TestingCRC Critical Reviews in Toxicology, 1984
- A new class of angiotensin-converting enzyme inhibitorsNature, 1980