IGG2 DEFICIENCY IN A HEALTHY BLOOD-DONOR - CONCOMITANT LACK OF IGG2-IMMUNOGLOBULIN, IGA-IMMUNOGLOBULIN AND IGE-IMMUNOGLOBULIN AND SPECIFIC ANTI-CARBOHYDRATE ANTIBODIES

  • 1 January 1983
    • journal article
    • research article
    • Vol. 51  (3) , 600-604
Abstract
Lack of serum IgG2, IgA and IgE was found in a health male adult blood donor. No secretory IgA could demonstrated. In vitro activation of lymphocytes did not induce IgA secreting cells although no class specific suppressor cells could be found. Normal or slightly subnormal titers to a variety of bacterial and viral antigens were demonstrated whereas anti-carbohydrate antibodies (anti-teichoic acid, anti-dextran and anti-pneumococcal polysaccharide) were virtually absent. Isoagglutinins and heteroagglutinins were present in somewhat lower concentrations than normal.