Relationships Between Molecular Interactions (Nucleotides, Lipids and Proteins) and Structural Features of the Bovine Brain 21‐kDa Protein
Open Access
- 1 November 1994
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 225 (3) , 1203-1210
- https://doi.org/10.1111/j.1432-1033.1994.1203b.x
Abstract
A cytosolic 21-kDa protein isolated from bovine brain was demonstrated to bind hydrophobic ligands, particularly phosphatidylethanolamine. It was encountered in several tissues and species; however, its accurate function remained partially unknown. In order to obtain information from its structural features, we built a molecular model which revealed it to possess a nucleotide-binding site. In the present research, we describe the affinity of the bovine brain 21-kDa protein for nucleotides, and its association with cytosolic proteins, small GTP-binding proteins and lipid droplets. Our results suggest that, through its association with small GTP-binding proteins, the 21-kDa protein is implicated in signal mechanisms during cell growth and maturation.Keywords
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