Interaction of HLA and immunoglobulin antigens in Type 1 (insulin-dependent) diabetes
- 1 November 1984
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 27 (5) , 504-508
- https://doi.org/10.1007/bf00290384
Abstract
We analyzed 88 unrelated subjects with Type 1 (insulin-dependent) diabetes and 64 sibling controls (maximum one per diabetic) for associations between immunoglobulin allotype antigens (GM and KM) and Type 1 diabetes. None were found. However, we did find interactions between GM, HLA-DR, and Type 1 diabetes (significant or of borderline significance after considering the effect of multiple tests): possession of Glm(2) appeared to increase susceptibility to diabetes in individuals who had HLA-DR3 but not HLA-DR4, while possession of G3m(5) appeared to increase susceptibility in individuals who had HLA-DR4 but not HLA-DR3. These results suggest that genetic predisposition to Type 1 diabetes is partially determined by alleles at the GM locus (or a locus in linkage disequilibrium with GM) interacting with alleles at the HLA-DR locus (or a locus in linkage disequilibrium with HLA-DR).This publication has 27 references indexed in Scilit:
- IgG AND IgA HEAVY CHAIN ALLOTYPES IN TYPE 1 DIABETESInternational Journal of Immunogenetics, 1983
- IMMUNOGLOBULIN ALLOTYPE MARKERS IN GLUTEN-SENSITIVE ENTEROPATHYThe Lancet, 1983
- Heterogeneity of insulin‐dependent diabetes–new evidenceClinical Genetics, 1982
- Genetic studies of insulin-dependent diabetes mellitus: segregation and linkage analysesTissue Antigens, 1982
- Insulin-Dependent Diabetes Mellitus: The Initial LesionNew England Journal of Medicine, 1981
- IgG Heavy-Chain (GM) Allotypes and Immune Response to Insulin in Insulin-Requiring Diabetes MellitusNew England Journal of Medicine, 1981
- Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated diseasesAnnals of Human Genetics, 1980
- IMMUNOGLOBULIN ALLOTYPES AND RESPONSE TO TETANUS TOXOID IN PAPUA, NEW GUINEAInternational Journal of Immunogenetics, 1979
- The Association of HLA with Juvenile Diabetes Mellitus in NewfoundlandTissue Antigens, 1978
- Population genetics of the human allotypes Gm, Inv, and A2mClinical Immunology and Immunopathology, 1977