Effect of Somatostatin on Bethanechol-Stimulated Gastric Acid Secretion and Gastric Antral Motility in Dogs with Gastric Fistula

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Abstract
The purpose of the present study was to evaluate the effect of somatostatin on gastric acid secretion and gastric antral motility in conssious dogs with gastric fistula. Infusion of bethanecol stimulated, dose-dependent acid secretion, whereas the frequency and strength of antral motility was maintained at a high level. Somatostatin inhibited, dose-dependent, the stimulated acid secretion, whereas the effect on antral motility was more complex, acting especially on the amplitude of the contractions. The effects of somatostatin were not altered by using .alpha.-adrenergic, .beta.-adrenergic, dopaminergic, and serotonergic blocking drugs. The dose-response kinetics with 4 doses of bethanechol with and without somatostatin showed inhibition of a non-competitivetype for gastric acid secretion and of a competitive type for antral motility with regard to amplitude.