THE EFFECTS OF DIENCEPHALIC-MESENCEPHALIC LESIONS ON ALDOSTERONE AND HYDROCORTISONE SECRETION1

Publisher Website
Google Scholar
Abstract
Brain stem lesions (high frequency coagulation) were made in 35 large male cats; 19 served as unlesioned controls. Four hours after lesioning, secretion rates of hydrocortisone and aldosterone were determined by isolation of the steroids from adrenal venous blood by paper chromatographic methods. Transection of the midbrain reticular formation did not alter aldosterone or hydrocortisone secretion rates. Destruction of the ventral diencephalon significantly reduced hydrocortisone and al-idosterone secretion. An even greater reduction in aldosterone levels was effected by lesions in the reticular formation of the midbrain and caudal diencephalon. These lesions likewise depressed the secretion of hydrocortisone. Secretion of aldosterone was significantly increased when the lesions extended caudally into the rostral half of the pons, without affecting hydrocortisone secretion.

This publication has 7 references indexed in Scilit: