Use of a computer in the calibration of dye dilution curves by a dynamic method.

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Abstract
Cardiac output measurements from continuously recorded indicator dilution curves in greyhounds were calibrated by the dynamic method. The results obtained by planimetric measurement of curve areas were used as a basis for the assessment of a computer which estimated the area of the curves after eliminating the effects of recirculation. In 40 consecutive experiments there was a 95% probability that the estimations of cardiac output by the 2 methods were within -10% to +8% of each other. The cardiac output in these studies was between 1.3 and 7.4 1/min. The computer provides evidence of the suitability of each curve for analysis, and when used with the dynamic method of calibration greatly reduces the time needed to estimate the cardiac output by the indicator dilution method.