A dynamic method for the calibration of dye dilution curves in a physiological system.

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Abstract
In 41 experiments involving 11 dogs the cardiac output was measured simultaneously by multiple arterial samples (Hamilton et al.) and from a continuously recorded dilution curve using the dynamic method of calibration (Sparling et al.). There was a 95% probability that the results were within - 11% to + 13.5% of each other, thus establishing the accuracy of this method of calibration in a physiological system.