Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis
Top Cited Papers
Open Access
- 22 June 2006
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 354 (25) , 2667-2676
- https://doi.org/10.1056/nejmoa052955
Abstract
Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and linked to fibroblast activation. Since platelet-derived growth factor (PDGF) stimulates the production of reactive oxygen species (ROS) and since IgG from patients with scleroderma reacts with human fibroblasts, we tested the hypothesis that patients with scleroderma have serum autoantibodies that stimulate the PDGF receptor (PDGFR), activating collagen-gene expression.Keywords
This publication has 13 references indexed in Scilit:
- Platelet-derived Growth Factor and Reactive Oxygen Species (ROS) Regulate Ras Protein Levels in Primary Human Fibroblasts via ERK1/2Journal of Biological Chemistry, 2005
- Following the Molecular Pathways toward an Understanding of the Pathogenesis of Systemic SclerosisAnnals of Internal Medicine, 2004
- Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosisArthritis & Rheumatism, 2002
- Oxidative stress in scleroderma: Maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathwayArthritis & Rheumatism, 2001
- Monocytes of Patients with Systemic Sclerosis (Scleroderma) Spontaneously Release In Vitro Increased Amounts of Superoxide AnionJournal of Investigative Dermatology, 1999
- Scleroderma Autoantigens Are Uniquely Fragmented by Metal-catalyzed Oxidation Reactions: Implications for PathogenesisThe Journal of Experimental Medicine, 1997
- Evidence of free radical–mediated injury (isoprostane overproduction) in sclerodermaArthritis & Rheumatism, 1996
- Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal TransductionScience, 1995
- Increased susceptibility to oxidation of low‐density lipoproteins isolated from patients with systemic sclerosisArthritis & Rheumatism, 1995
- Preliminary criteria for the classification of systemic sclerosis (scleroderma)Arthritis & Rheumatism, 1980