Transependymal transport of thiocyanate

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Abstract
The transependymal movement of thiocyanate (SCN−) was measured in the isolated choroid plexus of the sheep. The movement of SCN− from CSF to choroidal venous blood was separated into a nonlinear (saturable) and linear (nonsaturable) component. It was believed that the former component represented the active transport of SCN− from CSF to blood across the choroidal ependyma since it occurred against a concentration gradient and was adversely affected by the presence of a competing anion (iodide) and derangement of cellular respiration. These findings strongly support the role of choroid plexus in rapidly clearing the intraventricular of CSF of SCN− by an active transport process.

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